A Statistical Approach for the Maximization of the Financial Benefits Yielded by a Large Set of MMFs and AEs

This article introduces a statistical approach for the maximization of the financial benefits yielded by software projects that have been broken down into a considerable number of minimum marketable features modules (MMFs) and architectural elements (AEs). As the statistical approach requires a polynomial computational effort to run and provides approximation solutions with an arbitrarily chosen degree of confidence, it allows managers and developers to be more confident about the rightness of the decisions they make with little additional computational effort

Superação de dormência e germinação de sementes de Macroptilium (Fabaceae).

Este trabalho teve como objetivo analisar a influência da dormência na porcentagem de germinação de sementes de acessos de Macroptilium, assim como observar a necessidade e efi ciência da escarifi cação mecânica na superação da dormência

Seleção de genótipos de Manihot glaziovii tolerantes ao estresse salino por meio de avaliação da germinação e crescimento inicial de acessos.

Este trabalho teve como objetivo avaliar a tolerância de acessos de M. glaziovii ao estresse salino durante a germinação de sementes

Animal housing in hot climates : a multidisciplinary view

Since energy balance, thermoregulation and environmental aspects of "high producingdairy cows" were thoroughly studied (Brody, 1945; Flatt et al., 1969; Berman et al., 1985),the high producing dairy cow more than doubled production with a body weight increase of about 10-20% which imposed a three fold increase of heat increment (Kadzer et al., 2002).There is an apparent world wide lack of realization that changes in the physical and geneticconstitution of cows may have affected their thermoregulatory capability in hot climate forexample, blood plasma fluctuation in volume and constituents (Maltz et al, 1994); as wellas how they cope with heat stress (Kadzer et al., 2002). As a result, research inthermoregulation in relation to housing facilities and cooling management falls behind(except for few exceptions seen below) the aggressive selection for increased productionthat livestock undergoes as well as changes in technology and housing materials. Therefore,most of the improvements in this area are farmers and designers initiatives based oncommon sense and experience.peer-reviewe

Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure

<p>Abstract</p> <p>Background -</p> <p>Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure. We evaluated these polymorphisms relative to clinical characteristics and prognosis of alarge cohort of patients with heart failure of different etiologies.</p> <p>Methods -</p> <p>We studied 501 patients with heart failure of different etiologies. Mean age was 58 years (standard deviation 14.4 years), 298 (60%) were men. Polymorphisms were identified by polymerase chain reaction-restriction fragment length polymorphism.</p> <p>Results -</p> <p>During the mean follow-up of 12.6 months (standard deviation 10.3 months), 188 (38%) patients died. Distribution of genotypes of polymorphism Arg16Gly was different relative to body mass index (χ²= 9.797;p = 0.04). Overall the probability of survival was not significantly predicted by genotypes of Gln27Glu, Arg16Gly, or Thr164Ile. Allele and haplotype analysis also did not disclose any significant difference regarding mortality. Exploratory analysis through classification trees pointed towards a potential association between the Gln27Glu polymorphism and mortality in older individuals.</p> <p>Conclusion -</p> <p>In this study sample, we were not able to demonstrate an overall influence of polymorphisms Gln27Glu and Arg16Gly of beta-2 receptor gene on prognosis. Nevertheless, Gln27Glu polymorphism may have a potential predictive value in older individuals.</p

Reproductive phenology of Dipteryx odorata (Aubl.) Willd (Fabaceae) in two forest areas in the Central Amazon

Long term phenological studies in tropical forests are scarce. A phenological study of Dipteryx odorata was carried out from 1974 to 2000 in two areas of Amazon Forest: Reserva Florestal Ducke (RFD) and Estação Experimental de Silvicultura Tropical (EEST). The objective was to compare the phenological patterns between the two areas, to verify the regularity of flowering and fruiting over a period of 27 years, and to verify the influence of climatic factors in these events. Five trees were marked in the RFD and five in the EEST; and were observed monthly for the presence of flowers, unripe and ripe fruits. The flowering and unripe fruiting presented an irregular pattern in both areas, and also varied with regard to duration and period of occurrence between years and seasons. Nevertheless, they presented similar frequency of occurrence during the 27 years of observation. On the other hand, the production of ripe fruits presented a different pattern, with three year intervals without ripe fruits in the RFD, and seven year intervals in the EEST. We concluded that the frequency of flowering and unripe fruiting was annual, and the frequency of occurrence of ripe fruiting was supra-annual, with an irregular pattern, and a duration from intermediate to extended. We also observed the occurrence of one to three year intervals between flowering and unripe fruiting episodes, and one to seven year intervals between episodes with ripe fruiting. The influence of climatic factors in the patterns observed was not clear. We suggest the rational use of natural products extracted from Dipteryx odorata, the "cumaru", especially the fruits, and the development of more long term studies, fundamental for understanding the reproductive phenological patterns as well as the resource offering patterns in tropical forests.Estudos fenológicos de longa duração em florestas tropicais são raros. Foi realizado o acompanhamento fenológico de Dipteryx odorata, no período de 1974 à 2000, em duas áreas de floresta amazônicaa Reserva Florestal Ducke (RFD) e Estação Experimental de Silvicultura Tropical (EEST). O objetivo foi observar os padrões fenológicos nas duas áreas, verificar a regularidade da floração e frutificação num período de 27 anos e a influência dos fatores climáticos nestes eventos. Foram marcados cinco indivíduos na RFD e cinco na EEST e observados quanto à produção de flores, frutos imaturos e maduros. A floração e a produção de frutos imaturos apresentaram padrão irregular nas duas áreas observadas, variando quanto a época de ocorrência e a duração entre anos e estações, mas apresentaram freqüência de ocorrência similar nos 27 anos observados. Para a fenofase frutos maduros este padrão foi diferente, com intervalos de até três anos sem ocorrência de frutos maduros, na RFD e de sete anos na EEST. Conclui-se que a freqüência de ocorrência das fenofases de floração e frutos imaturos foi anual e a de frutos maduros supra-anual, todas com padrão irregular e duração de intermediária a prolongada. Ocorreu variação de um a três anos entre episódios de floração e frutos imaturos e de um a sete anos entre episódios de frutos maduros, não ficando evidente, nesta análise, a influência dos fatores climáticos nos padrões observados. Sugere-se o uso racional dos produtos derivados de Dipteryx odorata, o cumaru, especialmente quanto à exploração de seus frutos e o desenvolvimento de mais estudos de longa duração, fundamentais para entender os padrões fenológicos reprodutivos e de oferta de recursos em florestas tropicais

The Relationship between Population Structure and Aluminum Tolerance in Cultivated Sorghum

Background: Acid soils comprise up to 50% of the world's arable lands and in these areas aluminum (Al) toxicity impairs root growth, strongly limiting crop yield. Food security is thereby compromised in many developing countries located in tropical and subtropical regions worldwide. In sorghum, SbMATE, an Al-activated citrate transporter, underlies the Alt(SB) locus on chromosome 3 and confers Al tolerance via Al-activated root citrate release. Methodology: Population structure was studied in 254 sorghum accessions representative of the diversity present in cultivated sorghums. Al tolerance was assessed as the degree of root growth inhibition in nutrient solution containing Al. A genetic analysis based on markers flanking Alt(SB) and SbMATE expression was undertaken to assess a possible role for Alt(SB) in Al tolerant accessions. In addition, the mode of gene action was estimated concerning the Al tolerance trait. Comparisons between models that include population structure were applied to assess the importance of each subpopulation to Al tolerance. Conclusion/Significance: Six subpopulations were revealed featuring specific racial and geographic origins. Al tolerance was found to be rather rare and present primarily in guinea and to lesser extent in caudatum subpopulations. Alt(SB) was found to play a role in Al tolerance in most of the Al tolerant accessions. A striking variation was observed in the mode of gene action for the Al tolerance trait, which ranged from almost complete recessivity to near complete dominance, with a higher frequency of partially recessive sources of Al tolerance. A possible interpretation of our results concerning the origin and evolution of Al tolerance in cultivated sorghum is discussed. This study demonstrates the importance of deeply exploring the crop diversity reservoir both for a comprehensive view of the dynamics underlying the distribution and function of Al tolerance genes and to design efficient molecular breeding strategies aimed at enhancing Al tolerance.CGIAR[G3007.04]McKnight FoundationFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)National Council for Scientific and Technological Development (CNPq

Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil.

Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naïve populations. By analysing 92 newly generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue virus serotype 4 during the 2012 outbreak in Rio de Janeiro. Phylogenetic analysis indicates that the outbreak was caused by genotype II, although two isolates of genotype I were also detected for the first time in Rio de Janeiro. Evolutionary analysis and modelling estimates are congruent, indicating a reproduction number above 1 between January and June, and at least two thirds of infections being unnoticed. Modelling analysis suggests that viral transmission started in early January, which is consistent with multiple introductions, most likely from the northern states of Brazil, and with an increase in within-country air travel to Rio de Janeiro. The combination of genetic and epidemiological data from blood donor banks may be useful to anticipate epidemic spread of arboviruses